Dante - 2003 anime

Dante is the main antagonist of the 2003 Fullmetal Alchemist anime, first introduced in Episode 32. She is a cold elderly woman and a formidable alchemist herself. As the true master of all Homunculi, Dante is responsible for setting in motion the events of the series and the challenges its protagonists must face along the way.

Dante does not exist in the manga, as the creator and leader of the Homunculi in the manga is an enigmatic being simply called "Father".

Dante first appears as the former alchemy teacher of Izumi Curtis, who in turn taught the protagonists Edward and Alphonse Elric. Soon after her meeting with the Elrics, Dante faked her death at the hands of the Homunculus Greed, who is in turn killed by Ed, although it is obvious to the viewer that her body was dead before Greed had arrived.
Much later in the series, it is revealed that Dante had transferred her soul to Lyra's body, thereby prolonging her life. Dante is actually around 400 years old and is able to escape death by continually transferring her soul to new, younger bodies with the aid of the Philosopher's Stone. Nearly 400 years ago, she was Hohenheim's lover, and together they lived for centuries using this technique. They even had a son; however, he died of mercury poisoning at a young age. Hohenheim's attempt to transmute him back to life created Envy.

The first Philosopher's Stone that Dante and Hohenheim made used those condemned as witches and those dying of the plague as the required human sacrifice. In the course of performing this transmutation, Hohenheim was nearly killed; Dante saved him by instinctively attaching his soul to the body of another man; thus the pair discovered "eternal" life. In addition to this first Stone, Dante and Hohenheim were responsible for the destruction of at least two ancient cities: one located where the present capital of Amestris, Central, now stands, and a "fabled lost city in the east" (in reality, Hohenheim's home city), each of which is said to have mysteriously disappeared overnight. The inhabitants of the cities were used as ingredients in the Stone, while the buildings were pulled underground with alchemy. However, some time prior to the beginning of the anime, Hohenheim left Dante, eventually meeting Trisha Elric twenty years prior and falling in love with her.
Suddenly left to fend for herself, Dante resorted to using the Homunculi to do her bidding. She seeks out Homunculi from the moment they are created (when an alchemist tries to bring a dead person back to life) and feeds them Red Stones, thus strengthening them. She convinces the Homunculi that they will be better off as true humans, and makes them believe that she can transform them into true humans with the power of the Philosopher's Stone. Hence, the Homunculi become her minions in helping her to create the Stone. In reality, she only wants the Stone for herself in order to continue cheating death. Only Pride and Envy seem aware of this. The former serves Dante in exchange for power and adulation while the latter does so to kill as many humans as possible.

Unwilling to risk creating a Philosopher's Stone herself, Dante seeks to manipulate someone else into unwittingly doing so for her. However, she reasons that only someone with nothing left to lose would go so far as to sacrifice the many human souls required to create a Philosopher's Stone. Thus she uses the Homunculi (especially Führer King Bradley, who is secretly the Homunculus Pride) to wage unceasing war, hoping to motivate a desperate alchemist to create a Philosopher's Stone, which the Homunculi would then steal for her. To this end, she orchestrates the slaughters in Ishbal and Lior, and later, to cover her tracks, she orders Pride to attack Drachma, a country to the north. In the latter campaign, she plans to use the chaos on the front lines as a cover for the planned assassinations of Roy Mustang and his subordinates by Envy, though he returned upon hearing that she disposed of Hohenheim and refused to help until she reminded him of the Elric brothers had the Stone, giving Envy the pleasure to kill Ed (his replacement) and get Al (the stone).

However, Dante's "immortality" is a lie, her body is literally rotting away because every time she transferred her soul she left a piece of her soul in her previous body, and over time her soul had been reduced by so much it cannot support her human form, so Dante had planned to transfer her soul into Rose's body next using the Philosopher's Stone that was inside Al's body. This way, she hoped to gain control of Ed, hoping Rose's feelings for him would allow her to control him and have him replace Hohenheim as her lover. But after Ed refused to aid her, Dante sent him away to the other side for a short while. When Ed did return and got killed by Envy, Al sacrificed himself to save his brother, destroying the Philsopher's Stone, while Ed's death manages to shock Rose out of Dante's control, to Dante's dismay. As she escape into the elevator to find Pride to help her exact vengeance, she is devoured by Gluttony, whom she had ironically rendered crazed and mindless earlier.

Last Words:You don't understand, do you Gluttony? Just hold on, we'll find you something to eat soon, okay?